The crash happened on US Rt 1 South near the ramp to Route 252 (Providence Road) around 8 a.m. on July 2, authorities say.
The driver of a transit van and two passengers have died, said the Delaware County District Attorney's Office. Their identities were not given.
The highway was closed between Exit: I-476 - Chester/Plymouth Meeting and Exit: PA 252 - Media/Newton Square. All lanes were reopened by 1:30 p.m.
The two-vehicle crash was initially reported to involve a trash truck on fire with people trapped, but dispatchers were unsure if that is what emergency crews discovered at the scene.
Check back here for updates.
Click here to follow Daily Voice Wallingford-Swarthmore and receive free news updates.